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KMID : 0043319910140020172
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Archives of Pharmacal Research
1991 Volume.14 No. 2 p.172 ~ p.175
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The Activity of Dopamine beta-Hydroxylase of Central Nervous System in Genetically Epilepsy Prone Rats
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Park YJ
Chung HJ/Lee KH/Ko KH
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Abstract
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Abnormality in the central noradrenergic system may be related to the seizure prone state in the genetically epilepsy prone rats (GEPR). The present work deals with the characterization of the deficit in noradrenergic system if susceptitibility and intensity of seizure are dependent on central noradrenregic activities by comparing the activities of dopamine beta-hydroxylase (DBH) which hydroxylates dopamine into noradrenaline. DBH activities were measured in 5 areas of brain of normal rats, naive GEPR, and severe GEPR. The results suggest that lower DBH activities in the midbrain of GEPRs may positively be coupled to the susceptibility to seizure, whereas the same characteristics of the naive or severe GEPR are not necessarily in parallel with the intensity of seizure.
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KEYWORD
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